Drilling in the ANWR Essay Example | Topics and Well Written Essays - 500 words

Drilling in the ANWR - Essay Example This may be financially much more feasible to the country in general, but in the long term it can have some negative effects. This is because the drilling can cause a lot of problems to the natural habitat. The drilling will cause a damaged environment, one which can not be cured easily. Because of scarcity, choices have to be made on a daily basis by all consumers, firms and governments. For a moment, just have a think about the hundreds of millions of decisions that are made by people in your own country every single day. Take for example the choices that people make in the city of London about how to get to work. Over six million people travel into London each day, they have to make choices about when to travel, whether to use the bus, the tube, to walk or cycle – or indeed whether to work from home. Millions of decisions are being taken, many of them are habitual (we choose the same path each time) – but somehow on most days, people get to work on time and they get home too! This is a remarkable achievement, and for it to happen, our economy must provide the resources and the options for it to happen.† (Tutor 2 u) As the excerpt suggests that the government had the chance and job of making decisions and at times this can get very difficult. The government should have probably allowed for the exploration and the exploitation, however, should have also made sure that the habitat is preserved in the best way possible. These situations are pretty common for governments throughout the

Pharmacology Essay Example | Topics and Well Written Essays - 3000 words

Pharmacology - Essay Example reaches the targeted site, while the remaining fraction of the drug interacts with other sites, with consequences of inefficient drug delivery and undesirable side effects. Insufficient aqueous solubility and protein binding characteristics of that inhibit crossing blood brain barriers are two examples of the manner in which the relevance of some drugs in clinical therapeutics gets limited. It is against this background that pro-drugs and their utility in overcoming the limitations of bioavailability and pharmacokinetics profiles has become a significant subject of study in pharmacology (Shek, 1994). A look at the history of pro-drugs shows that understanding of pro-drugs and their pharmaco-kinetics in the human body came more as a result of after the introduction of the drugs for therapeutic purposes. The introduction of phenacetin as a therapeutic agent dates back to 1887, but it took till 1949 for the realization that paracetamol was the active metabolite of phenacetin, which resulted in the gradual erosion of phenacetin as a therapeutic agent to be replaced by paracetamol, demonstrating that many of the pro-drugs result from metabolism in the human body. (Pleuvry, 2006). This understanding of the possibility of enzymatic action to create active therapeutic agents has now become the basis of overcoming the problems of potential drug candidates demonstrating poor therapeutic effects, because of poor bioavailability and pharmacokinetic profiles. Kratz et al, 2008, define pro-drugs as â€Å"derivatives of a drug that are metabolized or activated in the body to release or generate the active drug – if possible at the site of action†. Thus pro-drugs are chemically modified versions of the pharmaceutical agent that needs to undergo a transformation in vivo for the release of the active drug. This feature of pro-drugs is employed to enhance the bioavailability and pharmacokinetic properties of pharmacologically potent compounds. In a majority of the cases